Application Of Transgenic Animals Wikipedia

In medical research transgenic animals are used to identify the functions of specific factors in complex homeostatic systems through over- or under-expression of a modified gene the inserted transgene.

Application of transgenic animals wikipedia. Transgenic applications used in animals to enhance disease resistance include the transfer of major histocompatibility complex genes T-cell receptor genes and immunoglobulin genes. For example we have transgenic models for diseases such. This is a brighter look for our future industrial wise.

I to obtain information on gene function and regulation as well as on human diseases ii to obtain high value products recombinant pharmaceutica. This results in a proportion of animals carrying the transgene in the germ line which may be high in some species eg. Applications of Transgenic Animals 1 Can use gene transfer to improve the productivity of livestock.

Applications Transgenic models for Alzheimer disease amyotrophic lateral sclerosis Huntington disease arthritis muscular dystrophy tumorigenesis hypertension neurodegenerative disorders endocrinological dysfunction coronary disease etc. Sheep goats pigs cows rabbits rats mice fish insects parasites and even humans have previously been used in this modification process. Transgenic animals are a source of several recombinant proteins like enzymes blood.

A foreign gene is inserted into these animals to see certain characteristics. Transgenic mice are used for testing the safety of vaccines. The animal which are genetically engineered called as transgenic animals produce and secrete such novel therapeutic proteins throughout their life.

Transgenic constructs bearing the immunoglobulin A LA gene have successfully introduced into pigs sheep and mice in an attempt to increase resistance against infections. Clotting factors vaccines monocl onal antibodies growth factors collagen fibrinogen. A number of methods are currently in use for the creation of transgenic animals.

The production of transgenic animals has focused mainly on producing models eg the mouse for basic and medical research. Transgenic animals are used to produce proteins which are important for medical and pharmaceutical applications. Transgenic animals are animals that are gene tically altered to have traits t hat mimic symptoms of spe cific.